N(fluorenylmethoxycarbonyl)-L-isoleucine pentafluorophenyl
fmoc-L-isoleucine pentafluorophenyl ester
CAS: 86060-89-1
Molecular Formula: C27H22F5NO4
N(fluorenylmethoxycarbonyl)-L-isoleucine pentafluorophenyl - Names and Identifiers
| Name | fmoc-L-isoleucine pentafluorophenyl ester |
| Synonyms | FMOC-ILE-OPFP Fmoc-Ile-OPfp Fmoc-L-Ile-OPfp FMOC-ISOLEUCINE-OPFP FMOC-L-ISOLEUCINE PENTAFLUOROPHENYL ESTER fmoc-L-isoleucine pentafluorophenyl ester N-ALPHA-FMOC-L-ISOLEUCINE PENTAFLUOROPHENYL ESTER N(fluorenylmethoxycarbonyl)-L-isoleucine pentafluorophenyl NALPHA-9-Fluorenylmethoxycarbonyl-L-isoleucine pentafluorophenyl ester N-alpha-(9-fluorenylmethyloxycarbonyl)-L-isoleucine pentafluorphenyl ester (2S,3S)-perfluorophenyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-methylpentanoate (2,3,4,5,6-pentafluorophenyl) (2S,3S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-pentanoate |
| CAS | 86060-89-1 |
| InChI | InChI=1/C27H22F5NO4/c1-3-13(2)24(26(34)37-25-22(31)20(29)19(28)21(30)23(25)32)33-27(35)36-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18,24H,3,12H2,1-2H3,(H,33,35)/t13-,24-/m0/s1 |
N(fluorenylmethoxycarbonyl)-L-isoleucine pentafluorophenyl - Physico-chemical Properties
| Molecular Formula | C27H22F5NO4 |
| Molar Mass | 519.46 |
| Density | 1.35g/cm3 |
| Melting Point | 73-75℃ |
| Boling Point | 596.3°C at 760 mmHg |
| Flash Point | 314.5°C |
| Vapor Presure | 3.47E-14mmHg at 25°C |
| BRN | 4221390 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.549 |
N(fluorenylmethoxycarbonyl)-L-isoleucine pentafluorophenyl - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
N(fluorenylmethoxycarbonyl)-L-isoleucine pentafluorophenyl - Introduction
fmoc-L-isoleucine pentafluorophenyl (fmoc-L-isoleucine pentafluorophenyl ester) is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless to light yellow solid
-Molecular formula: C34H29F5NO4
-Molecular weight: 619.59g/mol
-melting point: about 110-120 ℃
-Solubility: Soluble in organic solvents such as dichloromethane, dimethylformamide
Use:
- fmoc-L-isoleucine pentafluorophenyl ester is commonly used in peptide synthesis in solid phase synthesis. It acts as an activator and can react with an amino acid or a carboxyl group of a polypeptide, thereby introducing fmoc-L-isoleucine into the polypeptide chain.
Preparation Method:
- fmoc-L-isoleucine pentafluorophenyl ester can be obtained by reacting fmoc-L-isoleucine with pentafluorophenol esterifying agent (such as pentafluorophenyl trifluoroacetate). The specific steps include adding the pentafluorophenol esterifying agent to N,N-dimethylformamide at frozen room temperature, then adding fmoc-L-isoleucine and stirring, then adding carbodiimide, and finally adding sodium hydroxide to adjust the pH value to obtain the target product.
Safety Information:
- fmoc-L-isoleucine pentafluorophenyl ester belongs to chemical reagents, should be careful operation. Proper laboratory practices should be observed during use, including the wearing of appropriate protective equipment (e. g., lab clothes, gloves, goggles, etc.).
-Avoid inhalation, ingestion or contact with skin and eyes. If exposed, rinse immediately with water and seek medical help.
-Keep sealed storage and avoid contact with oxygen, flammable substances, etc. to prevent fire or explosion hazards.
-Please dispose of the waste of this compound properly and follow the relevant local waste disposal regulations.
Nature:
-Appearance: Colorless to light yellow solid
-Molecular formula: C34H29F5NO4
-Molecular weight: 619.59g/mol
-melting point: about 110-120 ℃
-Solubility: Soluble in organic solvents such as dichloromethane, dimethylformamide
Use:
- fmoc-L-isoleucine pentafluorophenyl ester is commonly used in peptide synthesis in solid phase synthesis. It acts as an activator and can react with an amino acid or a carboxyl group of a polypeptide, thereby introducing fmoc-L-isoleucine into the polypeptide chain.
Preparation Method:
- fmoc-L-isoleucine pentafluorophenyl ester can be obtained by reacting fmoc-L-isoleucine with pentafluorophenol esterifying agent (such as pentafluorophenyl trifluoroacetate). The specific steps include adding the pentafluorophenol esterifying agent to N,N-dimethylformamide at frozen room temperature, then adding fmoc-L-isoleucine and stirring, then adding carbodiimide, and finally adding sodium hydroxide to adjust the pH value to obtain the target product.
Safety Information:
- fmoc-L-isoleucine pentafluorophenyl ester belongs to chemical reagents, should be careful operation. Proper laboratory practices should be observed during use, including the wearing of appropriate protective equipment (e. g., lab clothes, gloves, goggles, etc.).
-Avoid inhalation, ingestion or contact with skin and eyes. If exposed, rinse immediately with water and seek medical help.
-Keep sealed storage and avoid contact with oxygen, flammable substances, etc. to prevent fire or explosion hazards.
-Please dispose of the waste of this compound properly and follow the relevant local waste disposal regulations.
Last Update：2024-04-10 22:29:15
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Product Name: Fmoc-L-Isoleucine Pentafluorophenyl Ester Visit Supplier Webpage Request for quotation
CAS: 86060-89-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 86060-89-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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